Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of tumorigenic glioblastoma stem cells

نویسندگان

  • Yue Liu
  • Fei Ye
  • Kazunari Yamada
  • Jonathan L. Tso
  • Yibei Zhang
  • David H. Nguyen
  • Qinghua Dong
  • Horacio Soto
  • Jinny Choe
  • Anna Dembo
  • Hayley Wheeler
  • Ascia Eskin
  • Ingrid Schmid
  • William H. Yong
  • Paul S. Mischel
  • Timothy F. Cloughesy
  • Harley I. Kornblum
  • Stanley F. Nelson
  • Linda M. Liau
  • Cho-Lea Tso
چکیده

1. Department of Surgery/Surgical Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. 2. Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, P.R.China 3. Cancer Institute, Zhejiang University, Hangzhou, Zhejiang, P.R.China 4. Department of Neurosurgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. 5. Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 6. Department of Medicine/Hematology-Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 7. Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 8. Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 9. Department of Psychiatry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 10. Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California.

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Cellular and Molecular Properties of Glioblastoma Stem Cells Autocrine Endothelin-3/Endothelin Receptor B Signaling Maintains

Glioblastoma stem cells (GSC) express both radial glial cell and neural crest cell (NCC)-associated genes. We report that endothelin 3 (EDN3), an essential mitogen forNCCdevelopment andmigration, is highly produced by GSCs. Serum-induced proliferative differentiation rapidly decreased EDN3 production and downregulated the expression of stemness-associated genes, and reciprocally, two glioblasto...

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Cancer Genes and Genomics Autocrine Endothelin-3/Endothelin Receptor B Signaling Maintains Cellular and Molecular Properties of Glioblastoma Stem Cells

Glioblastoma stem cells (GSC) express both radial glial cell and neural crest cell (NCC)-associated genes. We report that endothelin 3 (EDN3), an essential mitogen forNCCdevelopment andmigration, is highly produced by GSCs. Serum-induced proliferative differentiation rapidly decreased EDN3 production and downregulated the expression of stemness-associated genes, and reciprocally, two glioblasto...

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Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells.

Glioblastoma stem cells (GSC) express both radial glial cell and neural crest cell (NCC)-associated genes. We report that endothelin 3 (EDN3), an essential mitogen for NCC development and migration, is highly produced by GSCs. Serum-induced proliferative differentiation rapidly decreased EDN3 production and downregulated the expression of stemness-associated genes, and reciprocally, two gliobla...

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تاریخ انتشار 2011